Linkage analysis of a DNA polymorphism proximal to the Duchenne and Becker muscular dystrophy loci on the short arm of the X chromosome.
- 1 June 1985
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 22 (3) , 179-181
- https://doi.org/10.1136/jmg.22.3.179
Abstract
The inheritance of a restriction fragment length polymorphism (RFLP) detected by a cloned DNA sequence (p754) from the short arm of the X chromosome has been studied in 14 Duchenne muscular dystrophy kindreds and six Becker muscular dystrophy kindreds. The linkage data obtained suggest that both the DMD and BMD loci are located in the same region (p21) on the short arm of the X chromosome at a distance of about 15 to 20 cM from the 754 locus. Data from families informative for both the p754 and L1.28 polymorphisms suggest that p754 is closer to the disease loci than is L1.28.This publication has 6 references indexed in Scilit:
- Duchenne Muscular Dystrophy Involving Translocation of the dmd Gene Next to Ribosomal RNA GenesScience, 1984
- Localisation of the Becker muscular dystrophy gene on the short arm of the X chromosome by linkage to cloned DNA sequencesHuman Genetics, 1984
- The use of linked DNA polymorphisms for genotype prediction in families with Duchenne muscular dystrophy.Journal of Medical Genetics, 1983
- Translocation (X;6) in a female with Duchenne muscular dystrophy: implications for the localisation of the DMD locus.Journal of Medical Genetics, 1981
- Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.Proceedings of the National Academy of Sciences, 1977
- Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.1974