Antigen/MHC Class II/Ig Dimers for Study of Uveitogenic T Cells: IRBP p161-180 Presented by both IA and IE Molecules

Abstract
Purpose. Detection and modulation of effector T cells specific to immunodominant epitopes is a central issue in autoimmune diseases. Experimental autoimmune uveitis is a model for human autoimmune uveitis, induced in B10.RIII mice with interphotoreceptor retinoid binding protein or with its immunodominant epitope encoded by residues 161–180.

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