Embryotoxic Effects of 5-Hydroxytryptamine During the Peri-implantation Period in the Rat

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Abstract
Administration of 5-hydroxytryptamine creatinine sulfate (5-HT) (5, 10, 20 mg/kg s.c.) to pregnant rats during the preimplantation period (1200 h, days 1-5) did not inhibit implantation. Administration to pregnant rats during the preimplantation period (0900 h, day 6) of 5-HT 5 mg/kg s.c. did not affect implantation or embryofetal development. 5-HT (10 mg/kg s.c.) produced a significant increase (P > 0.01) in the resorption rate (31.8%) and severe cardiovascular or ophthalmic malformations in 5.3% of viable fetuses. 5-HT (20 mg/kg) produced a resorption rate (97.2%) virtually incompatible with the continuance of pregnancy. Histological examination of uterine preparations made from day-6 pregnant rats sacrificed 6, 24 and 30 h after receiving 5-HT (20 mg/kg s.c.) showed, in 30-h postinjection preparations, toxic effects at implantation sites (uterine lumen completely deprived of epithelial layer and filled with cellular debris and complete degeneration of implanted embryos) but no toxic effects between implantation sites.

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