Summary of a Workshop on Immunosuppression in the Management of Type I Diabetes Mellitus (IDDM)

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Abstract
Immunotherapputic interventions are now being used in the treatment of a number of diseases thought to be of immune origin or to have a major component involving the immune system. These diseases include various vasculitides, rheumatoid arthritis, multiple sclerosis, glomerulonephritis, and a large number of hematologic disorders. Recent evidence suggests that insulin-dependent (Type I, juvenile-onset) diabetes mellitus (IDDM) may have an important autoimmune component in most, if not all, cases,1 possibly triggered by a viral infection. This evidence includes round-cell infiltration in the endocrine pancreas, circulating islet-cell antibodies as measured by several different techniques, an association with certain HLA alleles . . .