Reactions of dialkoxycarbenes with tethered triple bonds to form heterocyclic compounds
- 1 February 1997
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 75 (2) , 120-128
- https://doi.org/10.1139/v97-016
Abstract
Dialkoxycarbenes with a tethered triple bond, generated from the corresponding oxadiazolines, undergo an intramolecular cyclization with the tethered alkyne moiety to give 3,3-dialkoxyvinylcarbene/1,3-dipole intermediates. The regioselectivity of the carbene cyclization is highly dependent upon the nature of the alkyne substituent. In the cases where an exocyclic vinylcarbene is generated, the vinylcarbene intermediate can undergo a synthetically useful [3 + 2] cycloaddition with either an appropriate olefin or an alkyne. This approach allows the rapid construction of some interesting heterocyclic ring systems. Keywords: carbene, dialkoxycarbene, vinylogous dialkoxycarbene, heterocycle.Keywords
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