Distinct clonal origin of low‐grade MALT‐type and high‐grade lesions of a multifocal gastric lymphoma
- 1 January 1999
- journal article
- case report
- Published by Wiley in Histopathology
- Vol. 34 (1) , 6-8
- https://doi.org/10.1046/j.1365-2559.1999.00568.x
Abstract
Low-grade mucosa-associated lymphoid tissue (MALT) lymphoma and high-grade B-cell non-Hodgkin's lymphoma (NHL) of the stomach may occur simultaneously. To determine the clonal relationship between these tumours, we compared the immunoglobulin heavy chain gene (IgH) rearrangements of low and high-grade components of a multifocal gastric NHL. The complementary determining region 3 (CDR3) of the IgH gene rearrangements were polymerase chain reaction (PCR) amplified, cloned and sequenced. The analysis of the CDR3 sequences rearranged by tumour cells of low-grade MALT and the high-grade NHL revealed different nucleic acid sequences. These findings suggest that low-grade MALT and high-grade B-cell components of multifocal gastric NHL may represent unrelated clones.Keywords
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