THE EFFECTS OF HYPOPHYSEAL GROWTH HORMONE ON THE METABOLISM OF Ca45IN HYPOPHYSECTOMIZED RATS*

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Abstract
ALTHOUGH the effects of hypophyseal growth hormone on bone histology have been thoroughly studied, little experimental work has been done on the interrelationships of this hormone and calcium metabolism. The few reports appearing in the literature have been inconclusive. Teel and Cushing (1930) noted that the urinary excretion of calcium in dogs was increased during the first few days following the injection of growth stimulating extracts. Pugsley and Anderson (1934) found that hypophysectomized rats on a low calcium diet showed a negative calcium balance which became positive on the administration of a crude growth hormone preparation. Krishnan (1942), using rats and guinea pigs, showed that injections of growth-promoting extracts caused calcium retention in these animals. It was with the object of studying the effects of pure growth hormone administration on the metabolism of Ca45 in hypophysectomized rats that the following experiment was performed.