Testosterone Control of Serum Levels of C4-Binding Protein in Mice
Open Access
- 1 September 1978
- journal article
- letter
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 121 (3) , 1213-1215
- https://doi.org/10.4049/jimmunol.121.3.1213
Abstract
Summary: Sex hormones control variations in the serum levels of C4-binding protein (C4-bp) in mice. The levels of C4-bp in castrated males are decreased as compared to the sham-operated controls. Castrated females injected with testosterone have higher levels of C4-bp than those injected with the vehicle alone. Effective “masculinization” of castrated females, with respect to C4-bp levels, was achieved by periodic inoculations of testosterone, and “feminization” of males was obtained by orchidectomy. In this regard, C4-bp behaves like other C components (C4, C5, C6) whose serum levels are strongly influenced by sex hormones.This publication has 0 references indexed in Scilit: