PHOTO-INHIBITION OF CHLAMYDOSPORULATION OF CANDIDA-ALBICANS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 15  (JUL) , 207-214
Abstract
C. albicans produced chlamydospores after 24 h in the dark at 27.degree. C, but the process was inhibited under adequate irradiation of light. The in vivo absorption spectra showed a main peak at 414 nm, and less important peaks at 430, 446, 477, 519, 549 and 560 nm. No bands were detected beyond 600 nm. A total inhibition of chlamydosporulation occurred at 414 nm (monochromatic light) for an initial energy of 2000 ergs .cntdot. cm-2 .cntdot. s-1. A 4000 ergs .cntdot. cm-2 .cntdot. s-1 irradiation energy was necessary to observe a marked inhibition at 460, 500 and 530 nm (chlamydospores and/or immaturity); this energy must be raised to 300,000 ergs .cntdot. cm-2 .cntdot. s-1 to observe a similar effect at 575 and 630 nm. Biological activity spectra were in full concordance with absorption spectra at 414 nm; no interpretation of absorption band at 460 nm is given, but total or partial inhibition could be explained by modulation of protoporphyrin activity.

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