Analgesics, antipyretics, and anti-inflammatory agents

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Abstract
Aspirin is present in many analgesic tablets. Salicylic acid is used in corn applications and in dermatologic ointments or as sodium salicylate for internal use. Salicylamide, salsalate, and sodium thiosalicylate are less toxic than aspirin and are used as weak analgesics given orally. Salicylates in toxic doses stimulate the central nervous system directly to cause hyperpnea and also produce a metabolic derangement with accumulation of organic acids. The principal manifestation of poisoning with acetaminophen is hepatic failure. It does not cause acid–base disturbances such as those that occur with the salicylates. Salicylates enhance the effects of coumarin anticoagulants and hypoglycemic drugs. Salicylates potentiate the effects of methotrexate by protein displacement. Salicylamide may greatly potentiate hepatic toxicity of acetaminophen. Salicylate, phenylbutazone and congeners, and indomethacin enhance the effects of cortisone by displacement. If corticosteroids are withdrawn during continuing salicylate therapy salicylate toxicity can occur.

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