SEARCH FOR CORRELATES OF RESISTANCE TO VIRULENT CHALLENGE IN MICE IMMUNIZED WITH COXIELLA-BURNETII

  • 1 January 1977
    • journal article
    • research article
    • Vol. 21  (5) , 422-430
Abstract
Mice immunized with live phase I or phase II C. burnetii, with killed phase I or phase II organisms or with trichloroacetic acid (TCAE) or phenol (PE) extracts were resistant to i.p. infection with phase I C. burnetii irrespective of whether or not they displayed phase I antibody response at the time of virulent challenge. Increased phagocytosis of purified phase I organisms by blood leukocytes or peritoneal exudate cells (PEC) was noticed only in mice with phase I agglutinating antibodies in their sera or peritoneal washings. Passive transfer of resistance was made possible only by sera containing phase I agglutinating antibodies. Adoptive transfer of immunity by spleen cells, but not by PEC, was achieved providing that these cells were taken from mice immunized with live phase I C. burnetii.

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