Pharmacokinetics of chloramphenicol in Chinese spot‐billed ducks (Anas poecilorhyncha)*

Publisher Website
Google Scholar
Abstract
The pharmacokinetic behavior of chloramphenicol in Chinese spot‐billed ducks (Anas poecilorhyncha) was investigated. Single doses of chloramphenicol were given by the intravenous (22 mg/kg), intramuscular (22 mg/kg), and oral route (55 mg/kg) to six, seven and six ducks, respectively. Serum samples were collected at various times and analyzed for chloramphenicol by a radio‐enzymatic procedure. The time—concentration curves after intravenous administration were described by one‐compartment kinetics. The mean half‐lives for the intravenous, intramuscular, and oral route were 102.5, 104.5 and 151.4 min, respectively. There was little individual variation in the time—concentration plots for either the intravenous or intramuscular route. However, following oral administration, there was considerable individual variation indicating erratic absorption. From the intravenously derived, pharmacokinetic parameters, dosage regimens applicable to either the intravenous or intramuscular route, were developed.