DISPOSITION OF MORPHINE-6-GLUCURONIDE AND MORPHINE IN HEALTHY VOLUNTEERS
Open Access
- 1 January 1991
- journal article
- clinical trial
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 66 (1) , 103-107
- https://doi.org/10.1093/bja/66.1.103
Abstract
The pharmacokinetics and subjective side effects of i.v. morphine sulphate 120 μg kg−1 and morphine-6-glucuronide (M6G) 30 μg kg−1 were determined in six healthy volunteers, using a placebo-controlled, single-blind randomized crossover design. Five of these volunteers underwent an additional (non-randomized) study of M6G 60 μg kg−1. Subjective side effects were similar following both drugs, but of shorter duration following M6G. Morphine was not detected after administration of M6G. For M6G 30 μg kg−1 the mean (SD) volume of distribution, elimination half-life and clearance were 29.38 (18.36) litre, 2.05 (1.2) h and 187.81 (37.41) litre h−1, respectively. These values were not significantly different from those obtained for M6G 60 μg kg−1. In all subjects the volumes of distribution and clearances were significantly smaller for M6G than for morphine, but the elimination half-lives were similar.Keywords
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