Pentylenetetrazol‐Induced Convulsion and Effect of Anticonvulsants in Mutant Inbred Strain El Mice
- 1 August 1986
- Vol. 27 (4) , 354-358
- https://doi.org/10.1111/j.1528-1157.1986.tb03553.x
Abstract
The El mouse is an inbred strain developed from ddY mice and is very susceptible to seizure. In El mice, convulsions could be induced by 18 mg/kg of pentylenetetrazol, which is an inert dose in ddY mice. The features of the convulsions were the same as those induced by the tossing-up procedure, a common method to evoke convulsions in El mice. Phenytoin, phenobarbital, valproate sodium, and ethosuximide clearly inhibited pentylenetetrazol-induced convulsions in El mice. These findings suggest that induction of convulsions by pentylenetetrazol in the El mouse is a simple mehtod as compared with induction of convulsions by the tossing-up procedure, and convulsions evoked by this method are a precise experimental model for the study of hereditary epilepsy and for the evaluation of anticonvulsant drugs.Keywords
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