THE SMOOTH MUSCLE CONTRACTING ACTION OF EFFLUENTS FROM THE ISOLATED GUINEA PIG ILEUM

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Abstract
An analysis was made of the effect of effluents from both outside and inside of the isolated guinea pig ileum segments. The action of the outside effluents was directed towards nervous elements of the test segment of the isolated ileum. According to the effect of atropine, morphine and hexamethonium, the action of theeffluent resembled that of 5-HT. Atropine and antazoline did not inhibit the effect of the effluent obtained from the inside of the donor gut upon the isolated rat fundus, but BOL and LSD did so in most experiments. The effect of this effluent upon the test segment of the guinea pig ileum was inhibited by morphine, or by a previous desensitation of the preparation by large doses of 5-HT. The smooth muscle stimulating effect of the effluent probably was due to its content in 5-HT and at least partly to some other as yet unidentified substance(s).

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