Proliferative Lesions of the Spleen in Male F344 Rats Fed Diets Containing P-Chloroaniline
Open Access
- 1 March 1980
- journal article
- research article
- Published by SAGE Publications in Veterinary Pathology
- Vol. 17 (2) , 200-205
- https://doi.org/10.1177/030098588001700208
Abstract
Fifty male F344 rats were given diets containing 500 mg/kg P-chloroaniline. Controls received diets without the chemical. Eighteen of the dosed rats developed proliferative lesions of the spleen. Lesions included parenchymal fibrosis and fatty infiltration, well and poorly differentiated fibrosarcomas, osteosarcomas and hemangiosarcomas. All dosed rats had focal and diffuse fibrosis and papillary hyperplasia of the splenic capsule.Keywords
This publication has 7 references indexed in Scilit:
- Neoplastic and nonneoplastic lesions in aging F344 ratsToxicology and Applied Pharmacology, 1979
- Fine Structure of the Reticular Cells in the Rat Spleen, with Special Reference to Their Fibro-Muscular FeaturesArchivum histologicum japonicum, 1977
- Detection of p-Chloroaniline in Chlorhexidine Solutions Using Thin-Layer ChromatographyJournal of Dental Research, 1976
- Toxicity of and biological monitoring for 1,3-diamino-2, 4, 6-trinitrobenzene and other nitro-amino derivatives of benzene and chlorobenzeneInternationales Archiv für Arbeitsmedizin, 1976
- Degradation and environmental fate of 1-(2,6-difluorobenzoyl)-3-(4-chlorophenyl)ureaJournal of Agricultural and Food Chemistry, 1975
- Biotransformation of 1-(4-chlorophenyl)-3,3-dimethyltriazene into 3-chloro-4-hydroxyanilineCancer Letters, 1975
- Biological Monitoring for Industrial Exposure to Cyanogenic Aromatic Nitro and Amino CompoundsAihaj Journal, 1974