Breathing Life into Polycations: Functionalization with pH-Responsive Endosomolytic Peptides and Polyethylene Glycol Enables siRNA Delivery
- 21 February 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 130 (11) , 3272-3273
- https://doi.org/10.1021/ja710344v
Abstract
No abstract availableKeywords
This publication has 11 references indexed in Scilit:
- Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytesProceedings of the National Academy of Sciences, 2007
- A dimethylmaleic acid–melittin‐polylysine conjugate with reduced toxicity, pH‐triggered endosomolytic activity and enhanced gene transfer potentialThe Journal of Gene Medicine, 2007
- Lactosylated Poly(ethylene glycol)-siRNA Conjugate through Acid-Labile β-Thiopropionate Linkage to Construct pH-Sensitive Polyion Complex Micelles Achieving Enhanced Gene Silencing in Hepatoma CellsJournal of the American Chemical Society, 2005
- Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA PolyplexesJournal of Biological Chemistry, 2003
- Bioinspired pH-Responsive Polymers for the Intracellular Delivery of Biomolecular DrugsBioconjugate Chemistry, 2003
- Endosomolysis by Masking of a Membrane-Active Agent (EMMA) for Cytoplasmic Release of MacromoleculesBioconjugate Chemistry, 2002
- Melittin Enables Efficient Vesicular Escape and Enhanced Nuclear Access of Nonviral Gene Delivery VectorsJournal of Biological Chemistry, 2001
- Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsNature, 2001
- A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.Proceedings of the National Academy of Sciences, 1995
- Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells.Proceedings of the National Academy of Sciences, 1991