Zinc and nitrate in the ground water and the incidence of Type 1 diabetes in Finland
- 17 February 2004
- journal article
- Published by Wiley in Diabetic Medicine
- Vol. 21 (3) , 256-261
- https://doi.org/10.1111/j.1464-5491.2004.01125.x
Abstract
In Finland, the risk of childhood Type 1 diabetes varies geographically. Therefore we investigated the association between spatial variation of Type 1 diabetes and its putative environmental risk factors, zinc and nitrates. The association was evaluated using Bayesian modelling and the geo-referenced data on diabetes cases and population. Neither zinc nor nitrate nor the urban/rural status of the area had a significant effect on the variation in incidence of childhood Type 1 diabetes. The results showed that although there was no significant difference in incidence between rural and urban areas, there was a tendency to increasing risk of Type 1 diabetes with the increasing concentration of NO3 in drinking water. The fact that no significant effect was found may stem from the aggregated data being too crude to detect it.Keywords
This publication has 58 references indexed in Scilit:
- Drinking water composition and childhood‐onset Type 1 diabetes mellitus in Devon and Cornwall, EnglandDiabetic Medicine, 2001
- Maternal and paternal age at delivery, birth order, and risk of childhood onset type 1 diabetes: population based cohortBMJ, 2001
- Influence of maternal age at delivery and birth order on risk of type 1 diabetes in childhood: prospective population based family studyBMJ, 2000
- The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.Environmental Health Perspectives, 1999
- Regional Differences in the Incidence of Insulin-dependent Diabetes Mellitus among Children in Finland from 1987 to 1991Annals of Medicine, 1997
- Evidence of a Relationship Between Childhood-Onset Type I Diabetes and Low Groundwater Concentration of ZincDiabetes Care, 1996
- Nitrate and Nitrite Intake and the Risk for Type 1 Diabetes in Finnish ChildrenDiabetic Medicine, 1994
- Nitrate Levels in Community Drinking Waters and Risk of IDDM: An ecological analysisDiabetes Care, 1992
- Feeding in Infancy and the Risk of Type 1 Diabetes Mellitus in Finnish ChildrenDiabetic Medicine, 1992
- Nitrate, nitrite, and N-nitroso compounds in Finnish foods and the estimation of the dietary intakesZeitschrift für Lebensmittel-Untersuchung und Forschung, 1990