Imipenem/cilastatin, an alternative treatment of pseudomonas infection in cystic fibrosis
- 1 April 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 21 (4) , 471-480
- https://doi.org/10.1093/jac/21.4.471
Abstract
Imipenem, a new N-formimidoyl thienamycin was given together with cilastatin to 20 patients with cystic fibrosis and pulmonary infection due to Pseudomonas aeruginosa. The antibiotic was given in short-term infusions for 9–14 days (mean 11·5) in a dose of 45–60 mg/kg body weight/day. Good clinical results were obtained in all patients with significant improvement of clinical score, pulse rate, vital capacity and FEV1·0) (P < 0·001). Blood PO2 increased and WBC decreased significantly. A slight increase in the minimum inhibitory concentration was noted during treatment but all strains examined were fully susceptible at follow-up one month later. The peak serum concentration was significantly increased in patients receiving the high dose of imipenem, but the sputum concentration was low in all patients and there was no difference in clinical or bacteriological outcome. The plasma and urinary clearance increased with body weight and was inversely correlated to clinical score. Imipenem/cilastatin appears a good alternative for the treatment of pulmonary infections caused by P. aeruginosa in cystic fibrosis.Keywords
This publication has 12 references indexed in Scilit:
- In-vitro activity of ciprofioxacin and other antibacterial agents against Pseudonwnas aeruginosa and Pseudomonas cepacia from cystic fibrosis patientsJournal of Antimicrobial Chemotherapy, 1985
- Pharmacokinetics of imipenem and cilastatin in patients with cystic fibrosisAntimicrobial Agents and Chemotherapy, 1985
- Renal clearance of gentamicin in cystic fibrosisThe Journal of Pediatrics, 1983
- FREQUENT ANTIBIOTIC THERAPY IMPROVES SURVIVAL OF CYSTIC FIBROSIS PATIENTS WITH CHRONIC PSEUDOMONAS AERUGINOSA INFECTIONActa Paediatrica, 1983
- Survey of Heat-Stable, Major Somatic Antigens of Pseudomonas aeruginosaInternational Journal of Systematic and Evolutionary Microbiology, 1983
- Urinary Recovery of N -Formimidoyl Thienamycin (MK0787) as Affected by Coadministration of N -Formimidoyl Thienamycin Dehydropeptidase InhibitorsAntimicrobial Agents and Chemotherapy, 1983
- ANTIBIOTIC TREATMENT OF STAPHYLOCOCCUS AUREUS INFECTION IN CYSTIC FIBROSISActa Paediatrica, 1982
- Pharmacokinetics of gentamicin in malnourrished infantsEuropean Journal of Clinical Pharmacology, 1982
- In vitro activity of N-formimidoyl thienamycin (MK0787)Antimicrobial Agents and Chemotherapy, 1980
- PSEUDOMONAS-AERUGINOSA INFECTION IN CYSTIC-FIBROSIS - DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF PSEUDOMONAS-AERUGINOSA PRECIPITINS DETERMINED BY MEANS OF CROSSED IMMUNOELECTROPHORESIS1977