PHARMACOLOGICAL EVIDENCE FOR THE INVOLVEMENT OF Na+ CHANNELS IN THE RELEASE OF CATECHOLAMINES FROM PERFUSED ADRENAL GLANDS
Open Access
- 1 March 1978
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 62 (3) , 359-361
- https://doi.org/10.1111/j.1476-5381.1978.tb08468.x
Abstract
Veratridine (0.1 mM) was found to be effective in producing an increase in the catecholamine output from perfused guinea-pig adrenal glands in the presence of high concentrations of hexamethonium (1.83 mM) and atropine (28.8 μM). The response to veratridine was abolished by removal of either Na+ or Ca2+ from perfusion media and by the addition of tetrodotoxin (0.1 μM). It is suggested that the response to veratridine may be due to an increase in the tetrodotoxin-sensitive Na+ permeability of chromaffin cell membranes.Keywords
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