Physical properties of pyrimidine and purine antimetabolites. I. The effects of salts and temperature on the solubility of 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil, 6-mercaptopurine, and thioinosine.

1 January 1976

journal article
research article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 24 (7) , 1654-1657
https://doi.org/10.1248/cpb.24.1654

Abstract

The effects of NaCl, Na2SO4 and NaI were studied on the solubility of 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil, 6-mercaptopurine and thioinosine. NaCl and Na2SO4 salted-out these antimetabolites while NaI salted-in them. The solubility of these antimetabolites at various temperatures was also measured. There was no indication of the transition in the stable form in the temperature range studied.

This publication has 0 references indexed in Scilit: