Chromosome changes in human lymphocytes after separate and combined treatment with divalent salts of lead, cadmium, and zinc

1 January 1981

journal article
research article
Published by Wiley in Environmental Mutagenesis

Vol. 3 (5) , 513-518
https://doi.org/10.1002/em.2860030503

Abstract

Unstimulated human lymphocytes in whole blood were treated for three hours with lead, cadmium, and zinc acetate separately and in combinations of two or three metal salts with different concentrations of between 10⁻³ and 10⁻⁸ moles, respectively. Untreated cultures and sodium acetate‐treated samples served as controls. Chromosome analysis from 48 cultures revealed higher incidences of chromatid‐type aberrations and gaps only for cultures exclusively treated with cadmium. The results are discussed under the aspect of heavy metal metabolism in human lymphocytes.

Keywords

This publication has 13 references indexed in Scilit:

Factors affecting the induction of chromosomal aberrations by cadmium in Chinese hamster cells
Cytogenetic and Genome Research, 1980
Chromosome studies on blood lymphocytes of men occupationally exposed to cadmium
Mutation Research/Genetic Toxicology, 1978
Metallothionein
Trends in Biochemical Sciences, 1978
Molecular-genetic effects of cadmium chloride
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977
Chromosome analyses of children after ecological lead exposure
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977
Chromosome analyses in cell cultures of the Chinese hamster after application of cadmiumsulphate
Mutation Research/Genetic Toxicology, 1976
Chromosome aberrations in lymphocytes after occupational exposure to lead and cadmium
Mutation Research/Genetic Toxicology, 1976
Die cytogenetische wirkung von blei in menschlichen peripheren lymphocyten in vitro und in vivo
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972
Chromosomenanalyse bei Verkehrspolizisten mit Erhöhter Bleilast
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972
Chromosomenanalysen in zellkulturen des chinesischen hamsters nach applikation von bleiacetat
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972