IMMUNOHISTOLOGY OF NORMAL AND OVARIAN-CANCER TISSUE WITH A MONOCLONAL-ANTIBODY TO PLACENTAL ALKALINE-PHOSPHATASE

  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (10) , 4496-4502
Abstract
A monoclonal antibody, designated NDOG2, was shown to react with placental alkaline phosphatase. It does not bind to liver, kidney, bone, or intestinal alkaline phosphatase enyzmes and showed a positive reaction with all of over 50 placentae [from humans]. Immunohistological studies have shown a reaction with respiratory bronchiolar epithelium of lung, endocervical gland epithelium, the epithelium of fallopian tube and certain reticular cells in the thymic medulla; no detectable staining with 10 other normal tissues including testis and tonsil; and a significant reaction with 9 of 13 ovarian cystadenocarcinomas and little or no staining with 4 malignant ovarian tumors of other histopathological types. The NDOG2 antibody may be of value as a marker in patients with ovarian cystadenocarcinoma.