Half-Life and Clearance of pH 6.8 and pH 4.25 Immunoglobulin G Intravenous Preparations in Patients with Primary Disorders of Humoral Immunity

Publisher Website
Google Scholar
Abstract
The half-life (t ½) and clearance of IgG and three antibodies — to tetanus, pneumococcus type 3, and pneumococcus type 7 — were evaluated in 38 patients who participated in a multicenter, double-blind, crossover study comparing two immunoglobulin G intravenous preparations, IGIV pH 6.8 and the new IGIV pH 4.25. IgG metabolism was evaluated after the sixth infusion by measuring the decline in concentration of IgG and specific antibody. The t ½ values of IgG varied greatly, but the mean values of 32 and 37 days are comparable to those determined in previous studies with use of radio labeled IgG and are longer than those reported in normal volunteers. The t ½ values for specific antibodies, especially those to tetanus, tended to be shorter than those for IgG. The clearance of IgG and antibodies also varied widely, but even though there was some relationship between the clearance and t ½ in individual patients, the poor correlation (R2 < .5) suggested that other factors, such as redistribution or loss of damaged molecules, are as important as the catabolic rate. Thus, clearance may be a more reliable parameter than t ½ in evaluating the metabolism of IgG.

This publication has 0 references indexed in Scilit: