Lymphocyte Subpopulations in Hodgkin’s Disease

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Abstract
Bukowski, Ronald M., Noguchi, Shiro. Hewlett, James S., and Deodhar, Sharad: Lymphocyte subpopulations of Hodgkin’s disease. Lymphocyte subpopulations were studied in the peripheral blood, lymph nodes, and spleens in a group of 17 patients with untreated Hodgkin’s disease. In 12 of 15 cases, diminished absolute levels of T-lymphocytes in the peripheral blood were found; however, this was correlated with total lymphopenia. No direct relationship between "Tlymphopenia" and diminished cellular immunity, as measured by phytohemagglutinin and pokeweed mitogen blast transformation, and delayed cutaneous hypersensitivity was demonstrated. In eight lymph nodes involved histologically by Hodgkin’s disease, a preponderance of T-lymphocytes was found when compared with a group of seven hyperplastic lymph nodes (78.2 ± 8.9% versus 54.5 ± 11.0%, P < 0.01). These latter data appear to be consistent with the hypothesis that the pathogenesis of Hodgkin’s disease involves a cell-mediated immune response to a neoplastic (antigenic) element.

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