THE ANTILIPAEMIC ACTIVITY OF LAMINARIN SULPHATE

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Abstract
When rabbits were fed a diet containing 1% cholesterol the blood serum levels of neutral fat, phospholipid, free and esterified cholesterol, and [beta]-lipoprotein were greatly increased. After the parenteral administration of laminarin sulphate or of heparin, all these were decreased, and the electro-phoretic mobility of the [beta]-lipoprotein was increased. Laminarin sulphate showed qualitatively the same effect as heparin on the hyper-lipaemia. There was no clear relationship between the magnitude of dosage of either compound and the degree of its antilipaemic effect.