Regional Cortical Dysfunction in Schizophrenic Patients Studied by Computerized Neuropsychological Methods
- 1 October 1985
- journal article
- research article
- Published by SAGE Publications in Perceptual and Motor Skills
- Vol. 61 (2) , 479-495
- https://doi.org/10.2466/pms.1985.61.2.479
Abstract
18 RDC-diagnosed schizophrenic patients (11 men, 7 women) were compared to 84 normal men with three computerized neuropsychological methods, assumed to reflect lateralized and frontal cortical functions: (1) Bilateral Finger Tapping and Finger Alternation, (2) Bilateral Trail Making, and (3) passively perceived Necker cube reversals. Schizophrenics differed from normals by (1) inferior Tapping/Alternation but only in the right hand, (2) inferior Trail Making, most pronounced for Form B, and (3) lower frequency of Necker cube reversals. Patients with previous neuroleptic medication and prior psychiatric hospitalizations were inferior in Trail Making and had fewer Necker cube reversals. The findings were interpreted in line with recent models of schizophrenia involving a left-hemisphere dysfunction/overactivation and a frontal dysfunction.This publication has 23 references indexed in Scilit:
- Frontal lobe functions in psychopaths.Journal of Abnormal Psychology, 1982
- Intra- and interhemispheric information processing in schizophrenia.Psychological Bulletin, 1982
- Optokinetic Nystagmus and Pursuit Eye Movements in SchizophreniaArchives of General Psychiatry, 1981
- Molecular pathology of schizophrenia: more than one disease process?BMJ, 1980
- Necker cube reversals, arousal and psychopathyBritish Journal of Social and Clinical Psychology, 1978
- A COMPREHENSIVE PSYCHOPATHOLOGICAL RATING SCALEActa Psychiatrica Scandinavica, 1978
- Neuropsychological differences among subtypes of schizophrenia.Journal of Abnormal Psychology, 1977
- NEUROPSYCHOLOGICAL, PATTERNS IN CHRONIC SCHIZOPHRENIAJournal of Nervous & Mental Disease, 1970
- The alternation of an ambiguous figure in paretics and schizophrenics.The Journal of Abnormal and Social Psychology, 1953
- Fluctuation of an ambiguous figure in dementia praecox and in manic-depressive patients.The Journal of Abnormal and Social Psychology, 1933