X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA.
- 1 December 1975
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 72 (12) , 4825-4829
- https://doi.org/10.1073/pnas.72.12.4825
Abstract
Good quality x-ray diffraction patterns have been obtained of polycrystalline fibers containing 2-hydroxyethanethiolato(2,2'2"-terpyridine)platinum(II) bound to calf thymus DNA by intercalation. The photographs strongly support the neighbor exclusion binding model in which electron-dense platinum atoms are regularly distributed at 10.2 A intervals, every other interbase pair site.Keywords
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