CLINICAL EVALUATION OF GITALIN IN THE TREATMENT OF CONGESTIVE HEART FAILURE

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Abstract
Amorphous gitalin was used in the treatment of congestive heart failure of varying causes, degrees, and duration in 68 patients. Gitalin was safely, comfortably, and effectively useful in initial digitalization, redigitalization, and maintenance digitalization of patients in heart failure. Cases are reported in which gitalin was of value in promptly and safely establishing digitalization and control of heart failure in 8 patients in whom digitalis, digitoxin, and digoxin were ineffective due to toxicity. No toxicity was encountered in any patient studied in this series. The clinical application of the wide difference between toxic and therapeutic dose in gitalin is an important advance in the pharmacology of cardiac glycosides.