cyclo-(L-Phenylalanyl-L-seryl) as an intermediate in the biosynthesis of gliotoxin
- 1 January 1978
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 11,p. 1336-1338
- https://doi.org/10.1039/p19780001336
Abstract
Feeding experiments with the four stereoisomers of cyclo-(phenylalanylseryl) have shown that only the LL-isomer is incorporated efficiently (48%) into gliotoxin in ‘Trichoderma viride’(Gliocladium deliquescens). cyclo-(L-[4′-3H]Phenylalanyl-L-[3-14C]seryl) gave gliotoxin with essentially unchanged 3H : 14C ratio. Successive feedings of non-radioactive cyclo-(L-phenylalanyl-L-seryl) and L-[U-14C]phenylalanine to cultures of T. viride led to the recovery of cyclo-(L-phenylalanyl-L-seryl) containing 1.3% of the radioactivity of the amino-acid. It is concluded that the cyclo-dipeptide is a natural metabolite of T. viride and is either an intermediate, or is interconvertible with an intermediate, on the biosynthetic pathway from phenylalanine to gliotoxin.This publication has 2 references indexed in Scilit:
- Analogue biosynthesis in Trichoderma viride: the formation of 3a-deoxygliotoxinJournal of the Chemical Society, Chemical Communications, 1976
- Gliotoxin, The Antibiotic Principle of Gliocladium fimbriatum. I. Production, Physical and Biological Properties1Journal of the American Chemical Society, 1943