PITFALLS IN IMMUNOFLUORESCENCE TESTING IN DERMATOLOGY .3. PEMPHIGUS-LIKE ANTIBODIES IN THE HORSE AND DIRECT IMMUNOFLUORESCENCE TESTING IN EQUINE DERMATOPHILOSIS

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 74  (4) , 305-311
Abstract
Indirect immunofluorescence testing for pemphigus-like antibodies was performed on 79 horses: 28 horses with various nonpemphigus dermatologic diseases, 21 horses with various nondermatologic diseases, and 30 normal horses. Pemphigus-like antibodies were detected in 6 horses: 3 normal horses with titers of 1:40, 2 horses with dermatophilosis at titers of 1:10 and 1:80, and 1 horse with lymphosarcoma at a titer of 1:320. Equine pemphigus-like antibodies are a potential source of misinterpretation and misdiagnosis in indirect immunofluorescence testing. Direct immunofluorescence testing for whole Ig, IgG, IgM and IgA was performed on skin lesions from 2 horses with dermatophilosis. Diffuse interecellular deposition of whole Ig and IgG was found in both horses. Equine dermatophilosis is a potential source of misinterpretation and misdiagnosis in direct immunofluorescence testing.

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