Stereospecific Synthesis ofN-(Diphenylmethylene)-α,β-didehydroamino Acid Methyl Esters from β-Hydroxy-α-amino Acids
- 1 January 1990
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1990 (09) , 779-781
- https://doi.org/10.1055/s-1990-27012
Abstract
N-(Diphenylmethylene)-α,β-didehydroamino acid methyl esters 2b-d are prepared with absolute geometric selectivity from inexpensive β-hydroxyamino acids through the intermediates N-(diphenylmethylene)- β-hydroxyamino acid methyl esters 1b-d. Besides, an easy conversion from E isomers to the corresponding Z isomers was performed, thus avoiding the use of the uncommon allo-β-hydroxyamino acids as starting materials.Keywords
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