Folding alphabets.
- 1 November 1999
- journal article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 6 (11) , 994-996
- https://doi.org/10.1038/14876
Abstract
A new computational approach optimizes searches for reduced protein folding alphabets that use fewer than 20 types of amino acids. The predicted optimal five-letter alphabet happens to be in agreement with the suggestive results of a recent experiment, but whether highly reduced alphabets are sufficient for truly protein-like properties remains an open experimental question.Keywords
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