Amino acids and peptides. XXV. Phosphorus in organic synthesis. XIV. Application of diphenyl phosphorazidate (DPPA) to the vasoactive intestinal peptide.

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Abstract
The synthesis of the N-terminal hexapeptide of the vasoactive intestinal peptide (VIP) [a gastrointestinal hormone], His-Ser-Asp-Ala-Val-Phe(II) was carried out by fragment condensation and stepwise elongation approaches using mainly diphenyl phosphorazidate (DPPA) as a coupling reagent.