HYPERPARATHYROIDISM PRODUCED BY DIET

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Abstract
Hyperparathyroidism in rabbits was produced by feeding a low Ca high P diet. This diet caused enlargement of the parathyroids to several times their normal size and hypertrophy of the cells and nuclei with an increase in the amt. of lipids in the cytoplasm. Aside from increased vascularity no important changes were found regularly in the bones. Serum Ca and P were low but within the normal range, while serum phosphatase was possibly less than normal. The Hamilton and Schwartz test for circulating parathormone was always high. Rabbits were kept in this state of chronic hyperparathyroidism for 21/2 yrs.

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