IFNγ inhibits porcine reproductive and respiratory syndrome virus replication in macrophages

1 June 1999

journal article
Published by Springer Nature in Archiv für die gesamte Virusforschung

Vol. 144 (6) , 1191-1200
https://doi.org/10.1007/s007050050578

Abstract

This study reports the effect of IFNγ on the replication of porcine reproductive and respiratory syndrome virus (PRRSV) in macrophages. Pretreatment with IFNγ profoundly affected PRRSV replication in porcine macrophages evaluated by reduction in titer and percentage of positive cells. The effect of IFNγ on PRRSV replication was both dose-dependent and related to the time of exposure. The mechanism of action was not due to blocking virus attachment. The inhibitory effect on PRRSV replication in macrophages suggests that IFNγ may play an important role in protection.

Keywords

VIRUS REPLICATION
IFN
TIME OF EXPOSURE
MECHANISM OF ACTION
INHIBITS PORCINE
REPLICATION IN MACROPHAGES
PORCINE REPRODUCTIVE

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