Interleukin-3 receptor in acute leukemia
- 4 December 2003
- journal article
- review article
- Published by Springer Nature in Leukemia
- Vol. 18 (2) , 219-226
- https://doi.org/10.1038/sj.leu.2403224
Abstract
Recent studies indicate that abnormalities of the interleukin-3 receptor (IL-3R) are frequently observed in acute myeloid leukemias (AMLs) and may contribute to the proliferative advantage of leukemic blasts. This review analyzes the evidences indicating that the IL-3R represents one of the target molecules involved in the stimulation of proliferation of AMLs, and the overexpression of the IL-3R chain may represent one of the mechanisms contributing to the development of a highly malignant leukemic phenotype. Furthermore, there is evidence that the IL-3R is a marker of leukemic stem cells, at variance with normal stem cells that are IL-3R-. Finally, the IL-3R may represent an important target for the development of new antileukemic drugs.Keywords
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