EFFECT OF PANCREAS TRANSPLANTATION ON LIPOPROTEIN LIPASE, POSTPRANDIAL LIPEMIA, AND HDL CHOLESTEROL

Publisher Website
Google Scholar
Abstract
Pancreas transplantation with systemic venous drainage of the graft causes elevated plasma levels of insulin, known to be a potent regulator of plasma lipoprotein metabolism. We studied 11 post-type I diabetic pancreas-kidney transplant recipients, 9 type I diabetic kidney transplant recipients displaying peripheral hyperinsulinemia due to subcutaneous insulin treatment, 11 nondiabetic kidney transplant recipients as controls for the effects of immunosuppressive medication, and 11 healthy control subjects, all matched for age, sex, and body mass index. We determined fasting lipids, lipoproteins and lipolytic enzymes, as well as postprandial lipid metabolism after a standardized oral fat load. High-density lipoprotein (HDL) cholesterol averaged 1.98 (0.40) mmol/L in pancreas- kidney transplant patients, clearly higher than that of kidney transplant recipients (1.52 (0.36) mmol/L, P

This publication has 0 references indexed in Scilit: