INDUCTION OF MORPHOLOGICAL TRANSFORMATION IN MOUSE C3H-10T1/2 CLONE-8 CELLS AND CHROMOSOMAL DAMAGE IN HAMSTER A(T1)C1-3 CELLS BY CANCER CHEMOTHERAPEUTIC-AGENTS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (7) , 2202-2208
Abstract
Various cancer chemotherapeutic agents including alkylating agents, antimetabolites and antibiotics or natural products were studied for their ability to produce morphological transformation in the C3H/10T1/2 clone 8 mouse cell line and chromosomal damage in the A(T1)C1-3 hamster cell line following a 24 h exposure of each agent at different concentrations. Those drugs that were known to be carcinogenic in vivo also produced morphological transformation and chromosomal damage, whereas those agents that were not shown to be carcinogenic in vivo produced neither transformation nor chromosomal lesions. The concentrations used for these studies were similar to those actually reached in the plasma of patients treated with these same drugs for malignant, as well as certain nonmalignant, conditions.