Transmission of P32-Labeled Candida Albicans to Newborn Mice at Birth

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Abstract
Introduction It has never been shown unequivocally that Candida albicans is transmitted from the mother's vagina to the newborn offspring during birth. This pathway of neonatal infection in humans has been inferred from the high correlation between maternal vaginal and neonatal oral candidiasis.1,2,3 There is no direct evidence, however, that the strain of C. albicans which is present in the maternal vagina is the self-same strain which is subsequently recovered from the newborn infant's mouth or gastrointestinal tract. It may be argued that the child may equally well have acquired C. albicans by cross infection during his sojourn in the newborn nursery. C. albicans is not normally present in the vagina or in the gastrointestinal tract of adult and newborn mice.4,5 Introduction of C. albicans into the mouse vagina shortly before parturition, and subsequent recovery of the organism from the newborn mice, would therefore constitute direct evidence that the

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