VARIABLES PREDICTING RESPONSE TO HIGH-DOSE CYTOSINE-ARABINOSIDE THERAPY IN PATIENTS WITH REFRACTORY ACUTE-LEUKEMIA

  • 1 August 1987
    • journal article
    • research article
    • Vol. 1  (8) , 580-583
Abstract
The cytotoxic effect of cytosine arabinoside (ara-C) is presumably mediated by cytosine arabinoside 5''-triphosphate (ara-CTP). We tested for a correlation between intracellular ara-CTP pharmacokinetics and clinical response among 51 patients who received high dose ara-C (3 g/m2 at 12-hr intervals) as therapy for refractory acute leukemia. After accounting for pretreatment clinical variables that correlated with response, measurement of ara-CTP pharmacokinetics added significant prognostic information. This provided a rationale for manipulation of schedules of high dose ara-C administration in those patients whose pharmacokinetic characteristics are inconsistent with response to an every 12-hr schedule.

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