THE REVERSIBILITY OF THE INHIBITION OF RAT BRAIN AND KIDNEY METABOLISM BY COLD

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Abstract
Measurement of rates of O2 consumption of rat kidney cortex slices and of O2 consumption and anaerobic glycolysis of rat cerebral cortex for successive periods of 1 hr. at temps. of 37.7[degree], 0.2[degree], and 37.7[degree] C showed that the capacity for these metabolic reactions was fully restored on rewarming. However, when cerebral cortex slices were exposed to the 0.2[degree]C level for periods of 3, 5, 7 and 24 hrs. the rates of O2 consumption observed during a subsequent period of 1 hr. showed progressive de-crease. In all cases the cooling or rewarming was complete in 15 mins.

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