Abstract
1. A study of the crude vital index of British Guiana is presented. From this there is evidence that malaria is the dominant factor in the birth/death ratio and that this disease recurs in periodic epidemics. The conditions reflected by this index show definite improvement since 1919. It is suggested that as a result of the cessation of immigration, the improving conditions indicated by the rising trend in the vital index curve and the falling trend in the malaria mortality rate, there may be evidence of the development in the population of premunition to the prevailing strains of malaria. 2. With the foregoing in mind, the crude vital index curves for locality and race afford a convenient means of ascertaining the effect of the colony's major health problem with regard to these specific factors.

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