CHARACTERISTICS OF BLAST CRISIS IN CHRONIC GRANULOCYTIC LEUKEMIA

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 49  (5) , 705-714
Abstract
The terminal phase of most patients with ph1[Philadelphia chromosome]-positive chronic granulocytic leukemia (i.e., blast crisis) resembles acute leukemia. The clinical and hematologic features of blast crisis in 73 patients with chronic granulocytic leukemia were reviewed. Two major morphological subgroups, lymphoblastic and myeloblastic, were identified. The lymphoblastic group had more profound thrombocytopenia and a greater number of blasts, while the myeloblastic group had more severe anemia. Extramedullary leukemia was documented in 27 patients. In 12 patients extramedullary leukemia preceded or occurred simultaneously with blast crisis in the bone marrow and peripheral blood. On the basis of this study hematologic criteria for the diagnosis of blast crisis were presented, and the importance of extramedullary leukemia in heralding the onset of blast crisis was emphasized.