Potentiation of morphine analgesia by caffeine
Open Access
- 1 April 1985
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 84 (4) , 789-791
- https://doi.org/10.1111/j.1476-5381.1985.tb17372.x
Abstract
Significant potentiation of morphine (5mg kg−1 s.c. or 1 mg kg−1 i.v.) analgesia (tail‐withdrawal reflex at 55°C) was observed in caffeine‐treated (100 mg kg−1 i.p.) rats as compared to the control group and lower doses of caffeine (2mg kg−1 i.p.) did not show this effect. Potentiated analgesia was reversed by naloxone. Pharmacokinetic or dispositional factors appear to be involved in part in this potentiation.Keywords
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