Cell Kinetics in Human Cyclic Neutropenia

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Abstract
Cell kinetics were studied at several periods in a patient with typical cyclic neutropenia. Peripheral blood granulocyte labeling showed an increased destruction in the preleukopenic phase. Bone marrow colony-forming cells and blood leukocyte colony forming activity were normal or above normal range. Major abnormalities were found in sequential studies of bone marrow proliferation measured by in vitro 3H-thymidine flash labeling. A fall in the labeling index of promyelocytes was seen in the 2nd part of the cycle. Incubation of normal human bone marrow cells with patient''s granulocytes showed a marked decrease in 3H-thymidine incorporation, compared with incubation with the same number of normal granulocytes. Human cyclic neutropenia may be due to a factor secreted by abnormal polymorphonuclears inhibiting meyloid proliferation.