Chromosome-Encoded Ambler Class A β-Lactamase of Kluyvera georgiana , a Probable Progenitor of a Subgroup of CTX-M Extended-Spectrum β-Lactamases
Open Access
- 1 December 2002
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (12) , 4038-4040
- https://doi.org/10.1128/aac.46.12.4038-4040.2002
Abstract
A chromosome-encoded β-lactamase gene, cloned and expressed in Escherichia coli from Kluyvera georgiana reference strain CUETM 4246-74 (DSM 9408), encoded the extended-spectrum β-lactamase KLUG-1, which shared 99% amino acid identity with the plasmid-mediated β-lactamase CTX-M-8. This work provides further evidence that Kluyvera spp. may be the progenitor(s) of CTX-M-type β-lactamases.Keywords
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