Transcriptional activation of the IL‐6 gene in human contracting skeletal muscle: influence of muscle glycogen content

Top Cited Papers
Publisher Website
Google Scholar
Abstract
SPECIFIC AIMSMeasurements across both working and non-working legs indicate that contracting skeletal muscle tissue is responsible for the dramatic rise in plasma interleukin 6 (IL-6) concentration during prolonged low intensity exercise. The purpose of the present study was to determine whether exercise activates transcription of the IL-6 gene in skeletal muscle and to determine the potential influence of muscle glycogen content on the IL-6 response to prolonged exercise in humans.PRINCIPAL FINDINGS1. Low pre-exercise muscle glycogen content in skeletal muscle elicits a greater plasma IL-6 response during prolonged exerciseTo determine whether muscle glycogen content influences the regulation of IL-6 expression during prolonged exercise, six male subjects completed an exercise/diet regimen that elicited either normal (control trial) or low (∼60% of normal; low glycogen trial) muscle glycogen levels. The next day, subjects performed 180 min of two-legged dynamic knee extensor exercise (50–60% of maximal w...
Funding Information
  • Danmarks Grundforskningsfond (504-14)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-45372)