Formulation, in-vitro release and therapeutic effect of hydrogels based controlled release tablets of propranolol hydrochloride
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 18 (19) , 2049-2066
- https://doi.org/10.3109/03639049209040919
Abstract
Matrix based controlled release tablets of Propranolol Hydrochloride (PHCL) were formulated using hydroxy propyl methyl cellulose (HPMC), sodium carboxy methyl cellulose (sod. CMC) and their combinations. The in-vitro dissolution kinetics revealed a zero order release for selected drug, HPMC and sod. CMC combination. The selected formulation was evaluated in mongrel dog by recording the isoprenaline induced tachycardia and measuring the inhibition of tachycardia. The results showed the sustaining therapeutic effect of the formulation.Keywords
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