THE UPTAKE AND AUTORADIOGRAPHIC LOCALIZATION OF TRITIATED OESTRADIOL IN THE RAT UTERUS AFTER LOCAL APPLICATION

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Abstract
SUMMARY: The distribution of radioactivity present in uterine tissue was investigated at various times after the injection of small amounts of tritiated oestradiol into the lumen of the uteri of ovariectomized rats. The highest amounts of radioactivity were present as free steroid 30 min. to 1 hr. after injection and a considerable amount was still present after 5 hr. Autoradiographs indicated that the distribution of labelling changed with time after injection, being heaviest initially in the epithelium, but being mainly located in or near the nuclei of both epithelium and stroma when maximum radioactivity was present. It is suggested that these sites are specific for oestrogens, and that many of the sites initially occupied are unspecific.

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